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Last updated on March 30th, 2020 at 6:40 pm
Profhilo: Is it Worth it?

Profhilo in Singapore

Profhilo is a Hyaluronic Acid injection treatment that hydrates your skin and also bio-remodels sagging skin by improving fat tissue renewal.

Used in Europe for years, Profhilo is now available in Singapore.

From $1200 per 2cc syringe (face area)

What are the benefits of Profhilo?

Deep skin hydration
Treats fine lines and wrinkles
Boost collagen and elastin levels
Less risk of lumpiness (No BDDE)
One of the highest concentration of HA on the market (64mg/2ml)

With aging and sun damage, your skin gets more fragile and dehydrated. This manifests as fine lines, dull, dry and saggy skin.

Profhilo tackles these issues holistically, naturally and with minimal downtime.

Known as an “injectable moisturiser” by some, Profhilo delivers high concentrations of hyaluronic acid to hydrate and stimulate collagen production in your skin.

Based on research studies, Profhilo is said to give 20% increase in skin hydration. Compared to regular skin boosters, Profhilo is 8 times more lasting in the skin than regular non cross-linked hyaluronic acid. Also, it gives 12 times increase of collagen and elastin in the skin. These benefits help you to achieve younger looking skin.

Compared to traditional skin boosters, Profhilo is delivered into your skin with only a handful of tiny injections – 10 injection points for a face treatment. It is possible to have a Profhilo treatment with close to zero down time. Almost a perfect treatment for a busy person who is looking for a treatment that hardly disrupts your schedule.

Profhilo is a foundational rejuvenating treatment for your skin. For even better anti-aging results, this treatment can be combined with lasers, chemical peels and HIFU for comprehensive age maintenance.

Profhilo has also been shown to have benefits for depressed acne scars, eczema and hand rejuvenation.

*Results & recovery will vary.

How does Profhilo work?

Profhilo is the first BDDE-free injectable Hyaluronic Acid for hydrating skin and treating skin laxity.

With one of the highest concentrations of HA in the market (64mg/2cc), the stabilised HA lasts in the skin for about 28 days.

Profhilo works because of 2 types of hyaluronic acid: L-HA and H-HA. This hybrid of HA allows hyaluronic acid to be released slowly and lasts longer allowing bioremodeling to take place.

L-HA as a hybrid complex is released slowly and hydrates your skin, providing the Hydro effect.

H-HA provides a stable HA architecture in the dermis that allows volumetric replacement, giving the Lift effect.

During this time, the slow release of HA kickstarts stimulation of 4 different types of collagen and elastin.

Histologically, the expression levels of type I and type III collagen and type IV and VII collagen in keratinocytes are increased. 

Is Profhilo suitable for you?

Profhilo is suitable for you if you are looking for more hydrated skin and firmer skin.

This is because Profhilo, which contains hyaluronic acid, helps to draw in moisture to your skin.

As a result, your skin will be more hydrated, giving you a more rejuvenated appearance.

The second function of it is collagen stimulation. This helps to improve signs of collagen loss like fine lines and loose skin.

Ultimately, Profhilo is a holistic anti-aging treatment that is suitable for one who is looking to rejuvenate their skin at its foundation.

Profhilo, Skin Booster, Rejuran: What’s the Difference?

Conventionally Hyaluronic Acid (HA) injections does one of the 2 things – Hydration or Volumisation. 

Although Profhilo also contains HA it does a lot more in boosting and stimulating 4 types of collagen and elastin. This restores the overall integrity of the skin and achieve a lifting effect. 

HA, as a skin booster is injected at multiple points under the skin to restore hydration and improve the elasticity of the skin at the injection site. However, this is not a frequently performed treatment as the associated downtime is not always socially acceptable. 

HA, as a filler, as its name suggest fills up volume that we lose when we age. This can result in an instant lifting effect by boosting the volume lost. However there is no effect on the skin and does not improve the skin texture.

Profhilo Vs Volite Vs Skinbooster (Restylane) Vs Biostimulators (Ellanse, radiesse) Vs Rejuran

Treatment regime
Ha concentration
Treatment area
2 treatment, 1 month apart
Currently for lower face only
Once treatment in year
Full face
Skin boosters (Restylane)
Once a month x 3 months, subsequent every 6 monthly
Full face
Once in 2 year
Targeted area
Once a month x 3 months, subsequent every 6 monthly
Full face

These are my views on the difference in effects of each substance. It is not difficult to understand why it’s a winner.

Collagen stimulation
Skin tightening
Skin lifting
Fine lines

Profhilo Review: Effective, Safe and Minimally Invasive?

Longevity – the NAHYCO Hybrid technology stabilised HA complex last 30x longer than other non cross-linked HA fillers. 

Less risk of lumps – Non BDDE cross linking allow this high HA concentration product to be highly spreadable and minimises risk of lumpiness compared to other injectable HA

Highest HA concentration in the market – maximal hydration effect 

Collagen and elastin bioremodelling – the hybrid complex stimulate collagen and elastin at the different depths of the skin – the epidermis dermis and the superficial adipose layer. This is different from the other biostimulators in the market like Ellanse and Radiesse, which work by inducing a low grade inflammatory response in the body. As such, this poses a risk of forming granuloma.

Is there downtime for Profhilo treatment?

You may have a little swelling at the injection point right after the appointment, but these will subside within 24 hours given that it is spreads easily into the intracellular space. 

Small bruises over the injection site can be easily concealed as large blood vessels are avoided with the specially designed BAP injection technique with fewer injection points (5 injection points per side of face).

How many injection points are required in Profhilo treatment?

For face treatment using Profhilo, a total of 10 injection points are needed. (5 injection points per side of your face.)

Compared to previous skinbooster treatments which generally require more than 30 injection points, Profhilo has the benefit of fewer injection points. This is reduces pain and reduces risk of bruising. This is especially advantageous for busy individuals who want to minimise recovery time.For neck treatment using Profhilo, a total of 10 injection points are needed.

Price of Profhilo in Singapore

Prices/cost of Profhilo range from $1200 upwards per treatment session.

Depending on your skin condition, more than 1 Profhilo treatment session might be needed to achieve desired results. 

You might also require lasers and other injectable treatments for holistic improvements.

Can Profhilo be combined with Lasers or Ultherapy?

Yes, combining Profhilo and energy based devices like Lasers and Ultherapy improves skin pigmentation and texture to improve your skin synergistically. 

Can Profhilo be combined with Botox/ Fillers?

Profhilo is an effective treatment on its own. 

However, it does not treat all your problems. A combination with botox and HA fillers can achieve better results. 

It will be best to consult your doctor to discuss your concerns.

Would you recommend Profhilo in treating skin laxity of the upper face?

The current injection technique developed is specifically for the lower face. Due to the nature of it being highly spreadable, the worry would be a spread of excessive amounts into the eyelids affecting its movements. 

There is potential use of Profhilo to treat upper face laxity but until a more developed protocol is recommended, I would suggest other injectable treatments, like Rejuran and skin boosters, and energy devices like Ultherapy and Ultraformer 3 HIFU.

How do I get the best results from Profhilo?

1. Accurate Diagnosis

Profhilo is a versatile and holistic treatment. However, certain problems cannot be solved with Profhilo. 

An accurate facial analysis and diagnosis of your problems ensures that the correct treatments are used to address your concerns.

An expert and honest doctor should be able to determine the appropriate treatments for you and explain if Profhilo is the right treatment for you.

2. Experience with Facial Injections

Profhilo is an effective treatment- in the right hands. 

Although Profhilo only requires 5 injections per side of your face, it does not mean that it is a technically easy procedure. 

Having extensive experience with facial anatomy and injection techniques is important to ensure that Profhilo is accurately injected to the correct layer of your skin for optimal results.

3. Comprehensive range of solutions

Profhilo might NOT be the only answer to your concerns. 

With a range of injectables (Botox, Fillers, Skin Boosters) and energy devices (Ultherapy, Ultraformer 3 HIFU, Pico Laser, Fractional Laser and INFINI), a comprehensive and customised treatment strategy beats treatment using only 1 type of technology. 



Medical Director

After graduating from the National University of Singapore, Dr Boey’s journey in aesthetics brought him to esteemed institutions such as Harvard Medical School, American Academy of Aesthetic Medicine and Queen Mary University of London in diverse cities like Seoul, London, Boston and New York.