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Profhilo versus Dermal Fillers: Comparison, Reviews, Price

Although Profhilo and dermal fillers contain hyaluronic acid, they do not function the same way. What’s the difference? Let’s find out more.

How does Profhilo work?

Profhilo introduces a new category in the injectable market – bioremodelling. Using a patented (NAHYCO) technology that thermally stabilise Hyaluronic Acid without the use of chemical cross-linking agents, it is able to demonstrate the unique function of remodelling multi-layer skin tissue – from improving hydration status and texture of the skin to treating moderate skin laxity.

What do fillers do?

Conventional HA dermal fillers contain HA that aims to volumise – for example in the use of augmenting a certain feature like a more prominent chin, a higher nose. The use of fillers in anti-aging is mainly to replace the volume that we lose in the mid-face as age. This provides an instant lift.

Since Profhilo and fillers are both HAs, what’s the difference?

The reason why they have different properties is due to the way that they are cross-linked and the molecular weight of HA.


Profhilo is stabilised with a patented thermal technology without the use of chemical bonds. This allows
  1. Low viscosity – it allows the product to have a high concentration of HA and yet ‘watery’ enough to spread 2cm from the injection point under the skin.
  2. Increase availability of Porfhilo to bind to water to provide deep hydration effects
HA fillers
  1. On the other hand, HA fillers are usually BDDE crosslinked to increase viscosity and G’ – which is important so that the fillers are to stay and shape and resist impacts of external pressure

Molecular weight

Profhilo contains patented hybrid HA complexes of a combination of high and low molecular weight. Low molecular weight complex is responsible for binding to water, providing the hydration effects. Whereas High molecular weight complexes provides a stable HA architecture in the dermis that allows volumetric replacement – giving the ‘Lift’ effect. The different molecular weights penetrate to the different depts of the skin – from the dermis to the superficial adipose layer to kickstart collagen and elastin bioremodelling process. This collagen building process results in a natural lifting effect. A dermal filler used to volumise an area usually contains high molecular weight HA cross-linked in BDDE. This will allow the filler to be higher in viscosity, more cohesive that will means that it will be structurally ‘harder’ to take the shape of the area where it ‘fills’. By structurally filling hollow areas where it fills

Profhilo versus Fillers: Comparison, Review, Price

Profhilo Dermal Fillers
Ingredients HA of different molecular weight 64mg/2mls per session High molecular weight 20-24mg/ml per syringe
Cross-linking Patented thermal NAHYCO technology BDDE (Chemically) cross-linked
Hydration +++
Bio-remodelling/ Collagen stimulation +++
Radiance +
Indication Skin laxity for moderate sagginess ~40 years Replace volume (of the midface for rejuvenation)
Treatment area Lower face, neck, décolletage. Possible area of upper face, body parts like knee, hands Usually for the volume replacement of the cheeks and mid face for rejuvenation.
Treatment regime 2 sessions, 1 month apart About once a year
Administration BAP technique, 10 points 1 or 2 point injection per treatment area
Downtime Minimal swelling that resolves in ~2 hours Minimal to no downtime
Pain + +
Cost/ Price  $1000-$1500/ session ~ $800 per syringe

Is Profhilo better than fillers?

That will depend on what you are trying to achieve. They treat very different problems – by identifying the problem that you want to treat, one treatment will work better than the other.

How does Profhilo lift differently from fillers?

Profhilo lifts by stimulating collagen and elastin that improves the integrity and elasticity of the skin. As collagen is laid down gradually, the results will take weeks to show. It also requires 2 sessions for best results. However, unlike fillers, it is an anti-aging product that treats the source of aging and not the symptoms. Whereas a filler provides more drastic and instant results that treats the symptoms, it does not stimulate collagen. Fillers can result in unnatural appearance, which is not likely for Profhilo as it does not lift by volumizing a certain area of the face.

Should Profhilo be done before or after fillers? Or can it be done concurrently?

It is safe for Profhilo to be done before or after fillers. Both Profhilo and fillers contain HA and it is not likely that profhilo interacts with fillers and it is possible that these can be done concurrently. However, Profhilo have advised against the use of Profhilo and other products in the same area on the same day. There are no studies to prove that Profhilo can prolong the effects of HA fillers but it is possible as it increase collagen production which can potentially decrease the rate at which the fillers are resorbed. As they are both products that helps to lift and rejuvenate the skin, they work synergistically to enhance results. For best results, please consult an expert doctor!


Medical Director

After graduating from the National University of Singapore, Dr Boey’s journey in aesthetics brought him to esteemed institutions such as Harvard Medical School, American Academy of Aesthetic Medicine and Queen Mary University of London in diverse cities like Seoul, London, Boston and New York.