Melasma Cream Cyspera® (Cysteamine): Reviews & Price in Singapore

Cysteamine (Cyspera) is one of the most commonly used melasma treatment cream in Singapore. The other commonly used melasma treatment cream is hydroquinone cream (tri-luma).

What is Cysteamine (Cyspera®) Melasma cream in Singapore?

Cysteamine (Cyspera®) is a novel pigment corrector for hyperpigmentation concerns like melasma, post-inflammatory hyperpigmentation and freckles. Naturally present in human body, Cysteamine reduces melanin in the skin epidermis, effectively correcting pigmented marks. Cysteamine is the natural product of metabolization of cysteine, a sulfur-containing amino acid that is naturally present in abundance in the human body. Once in contact with the air, the fast oxidation of cysteamine produces a red cap at the surface of its tube and a slight sulphur-like odor. This is normal and harmless.

Widely used in Singapore, Cysteamine is a cosmeceutical that is produced in Switzerland.

What are the benefits of Cysteamine/ Cyspera in Singapore?

Intensive pigment corrector for hyperpigmentation concerns.

• Significant pigment correction effectiveness
• Superior benefit / risk ratio
• Bio-compatible, well tolerated, and not photosensibilising
• Non-cytotoxic, non-mutagenic non-carcinogenic

12-weeks full solution cycle (1.8oz / 50g, 5% cysteamine hydrochloride)

What are the expected results of Cysteamine/ Cyspera?

90% of users noticed moderate to significant improvements with Cysteamine/ Cyspera.

Start to see significant visible improvements in pigmentation after 2-3 months of once-daily application. Once the desired results are achieved, maintain your new complexion with twice weekly applications of Cysteamine/ Cyspera®. The efficacy of Cysteamine/ Cyspera® is linked to the chronicity, or consistency, of exposure over a period of time rather than the daily duration of exposure. Ensure that you comply strictly to the daily application routine. Do not wash off your face before but after the 15 minutes application.

What is the price of Cysteamine/ Cyspera in Singapore?

The price of Cysteamine (Cyspera) in Singapore costs from SGD$250 to 300.

Cysteamine/ Cyspera versus Hydroquinone

Studies show that Cysteamine is as effective as Hydroquinone. In addition, Cysteamine/ Cyspera is safe for prolonged long-term use.

In certain cases, Cysteamine is effective in patients who have stubborn melasma that is resistant to hydroquinone.

References: https://www.ncbi.nlm.nih.gov/pubmed/30537063

How do I use Cysteamine/ Cyspera?

1. Do not wash the skin before use.

Do not wash the skin before application. If necessary to wash, wait for one hour before application.

2. Leave for 15 minutes.

Apply a thin layer on the skin (a warming sensation or mild tingling may occur and last up to 30 minutes). Leave on for 15 minutes

3. Wash off.

Remove by washing the area with a gentle face cleanser. Gently pat your face dry

4. Moisturise

Moisturise the area. Maintain skin hydration during the day.

Intensive phase: Once per day for 16 weeks 

Maintenance phase: Twice-weekly, once per day

The use of high SPF sunblock is highly recommended year-round for sun damage protection. Cysteamine® is not a photosensitizer. It can be applied regardless of the sun intensity and on any skin phototypes. Cysteamine® contains ingredients to reduce hyperpigmentation. Undesirable effects may occur ; learn more under the “Non-significant Undesirable Effects“ section.

When can I see results from Cysteamine/ Cyspera cream for melasma treatment in Singapore?

The first signs of pigment correction becomes visible after 6 weeks of once-a-day application. Optimal results are achieved after 8 to 12 weeks of once-daily application. Once the desired results are achieved, maintain your new complexion with twice weekly applications of Cysteamine/ Cyspera cream®.

The efficacy of Cysteamine Cream (Cyspera®) is linked to the chronicity, or consistency, of exposure over a period of time rather than the daily duration of exposure. 

Ensure that you comply strictly to the daily application routine: not washing off your face before but after the 15 minutes application. A burning sensation and mild redness might occur immediately after application, but it will usually disappear after 30 minutes. This is a normal reaction and may happen during the first few days of application.

No significant side effects, other than light to mild irritation are reported in only a few cases. In case of sustained redness, irritation or dry-skin, suspend Cysteamine (Cyspera®) application and carefully hydrate the area with your basic hydration cream. You may gradually resume Cysteamine (Cyspera®) application once the skin is balanced again — once again, not washing off your face before, but after the 15 minutes application.

Is Cysteamine/ Cyspera safe for pregnant and breast-feeding women?

No study for use in pregnant and breast-feeding mothers has been conducted and hence cysteamine must not be used during pregnancy or when breast-feeding. Avoid using cysteamine (Cyspera®) if you, or somebody in your close family, suffer(s) from vitiligo. Do not mix with other skin routines. Keep out of reach of children. Store at room temperature.

What are the side effects of Cyspera/ Cysteamine cream?

Cyspera/ Cysteamine is generally very safe.

The non-significant undesirable side-effects of Cysteamine/ Cyspera are: redness, dryness or irritation of the skin. A burning sensation and mild redness might occur immediately after application, but it will usually disappear after 30 minutes. This is a normal reaction and may happen during the first few days of application.

After 6 weeks of application of cysteamine, the risk of skin irritation reduces considerably (skin hardening), and higher exposure times are usually well tolerated (although it is not necessary to increase the exposure time).

How can I minimise side-effects of Cysteamine/ Cyspera?

You can minimise side-effects by:

• Avoid washing your face just before applying cyspera/ Cysteamine.
  (minimum 1h interval to be respected)
• Avoid prolonged application time of cyspera/ cysteamine.
• Avoiding concomitant use with other topical products.

Undesirable effects are very rare if:

• 15 minutes of exposure
• 1 hour interval between washing and application

Is Cysteamine/ Cyspera safe for long-term use?

There is no limit for the long-term use of cysteamine based on research and clinical studies.

Cysteamine (Cyspera®) Results Reviewed

Cysteamine (Cyspera®) is effective for melasma and other forms of hyper-pigmentation in Singapore. 

Cysteamine (Cyspera®) Official Website.

Great results are achieved if combined with sun protection and pigment removal lasers like Pico Lasers.