Melasma Cream Cyspera (Cysteamine): What Is It, How It Works and 4 Benefits

Melasma can be frustrating to manage. Those persistent dark patches and spots on the skin, often triggered by hormonal changes or sun exposure, can feel like a never-ending concern. But what if there was a targeted way to manage it that suits different skin types and offers a long-term approach to skin care?

Enter Cyspera (Cysteamine), a topical cream aesthetic professionals recommend for pigmentation concerns, including melasma. This blog explores what Cyspera is, how it works and its benefits so you can determine if it’s the right product for you.  

What is Cysteamine (Cyspera®) Melasma Cream?

Cyspera is a topical treatment for melasma and other pigmentation concerns like post-inflammatory hyperpigmentation, dark spots and some acne scars. Its active ingredient, cysteamine, is naturally found in human cells and has been formulated to target melanin production directly.

Unlike traditional pigmentation treatments, Cyspera does not rely on harsh bleaching agents, making it suitable for long-term use. Its approach focuses on reducing persistent brown patches while being gentle on the skin, and it has gained popularity for improving uneven skin tone in a safe and manageable way. Cysteamine (Cyspera®) melasma cream is now available in Singapore and other Southeast and East Asian countries.

Benefits of Using Cysteamine  

Cyspera offers several benefits for individuals dealing with melasma and other hyperpigmentation issues.  

Effective for Melasma and Hyperpigmentation

Cyspera targets stubborn pigmentation issues that are often resistant to other treatments. Whether melasma, post-inflammatory hyperpigmentation, or persistent brown patches, cysteamine has shown significant results in visibly improving skin tone.  

Safe for Long-Term Use

Cyspera is formulated for extended use without the risk of skin thinning. This makes it a reliable option for those seeking a sustainable approach to managing pigmentation.  

Suitable for Various Skin Types

Whether you have sensitive, normal, or combination skin, Cyspera is designed to work across different skin types. Individuals with darker skin tones may be prone to pigmentation issues and they may find Cyspera a suitable option to address this.  

Minimal Side Effects

Cyspera’s application process is straightforward and typically involves mild irritation when used correctly. Unlike many alternative treatments, it carries a lower risk of irritation, making it a user-friendly choice.

How Does Cyspera Work?

To understand how Cyspera works, it’s essential to know a bit about melanin production. Melanin is a pigment naturally present in our bodies that gives our skin, hair and eyes their colour. Overproduction of melanin in certain areas leads to pigmentation issues such as melasma.

Cyspera inhibits the tyrosinase enzyme, a key player in melanin production. By interrupting this process, Cyspera reduces excess melanin and helps even out skin tone. Additionally, it combats oxidative stress in the skin, protecting cells from environmental damage that can worsen pigmentation problems.

What makes Cyspera unique is its targeted action. While it focuses on pigmentation concerns, it does not affect systemic processes in the body, making it a safe choice for regular use.  

How to Use Cyspera (Cysteamine)?

Using Cyspera effectively involves consistency and the right technique. Here is a simple guide to help you get started:

• Frequency. Gently pat Cyspera once daily for 16 weeks or as directed by your aesthetic practitioner. Depending on your skin’s sensitivity, you may begin the melasma treatment once or twice a week. After 16 weeks, you can switch to once a day twice weekly for maintenance.
• Application: Apply a thin layer of the cream to clean, dry skin and leave it on for 5 to 15 minutes. Wash it thoroughly and follow up with a gentle moisturiser to maintain skin hydration.  
• Time of use. It can be used in the morning or at night as long as you apply it on unwashed skin. If you need to wash your skin, make sure to wait for an hour before applying the cream.
• Post-application care: Always use sunscreen daily to protect your skin from UV damage and optimise the treatment results. 

Steps	Details
Apply	Spread a thin layer of Cyspera evenly on unwashed skin.
Wait	Leave it on for 5 to 15 minutes
Rinse	Rinse off completely
Moisturise and protect	Apply moisturiser and daytime sunscreen

Ensure you perform a patch test before full application and consult with a professional if you experience irritation.

Ideal Candidates for Cyspera (Cysteamine)

Cyspera could be a good choice if you’re dealing with conditions like:

• Melasma or persistent pigmentation  
• Uneven skin tone resulting from hormonal or environmental causes  
• Post-inflammatory pigmentation due to acne or other skin conditions  

Its versatility also makes it suitable for various skin types and tones.  

What Are the Expected Results of Cysteamine/Cyspera?  

Results with Cyspera typically appear gradually and improve with consistent use.

• 2 weeks – Mild reduction in pigmentation and improved skin texture  
• 4-6 weeks – Noticeable fading of darker areas and more uniform skin tone  
• 8+ weeks – Stronger pigment reduction and increased skin brightness  

What is the Price of Cysteamine/Cyspera in Singapore?  

Cyspera in Singapore typically costs between $250 to $300. While this may seem higher than many off-the-shelf products, the targeted treatment and long-lasting results from this pigment corrector offer significant value.  

If you’re looking for personalised advice on using this product or any other skin care treatments, we recommend consulting with an aesthetic practitioner like Sozo Clinic’s Dr Justin Boey to provide additional insights.

Side Effects of Cyspera (Cysteamine)

While Cyspera is generally well-tolerated, some side effects may occur. Here’s what to watch for and how to manage them:

• Mild redness or tingling. Mild irritation may occur after application but usually fades quickly. If it persists or becomes uncomfortable, consult your aesthetic professional.
• Irritation from incorrect use. Using too much or not following the instructions can cause temporary irritation. Be sure to follow the guidelines for best results.

Always do a patch test on a small skin area before full use to check for adverse reactions or allergies. This helps ensure compatibility and avoid side effects.

Alternatives to Cyspera for Pigmentation Treatment

While Cyspera offers a safe and effective solution for melasma treatment, alternative options like hydroquinone or laser treatments can also address pigmentation concerns. These treatments can also address other skin concerns, including acne scars.

How Does Cyspera Compare to Hydroquinone? 

Feature	Cyspera	Hydroquinone
Safety	Suitable for long-term use	Risk of redness and dryness
Efficacy	Gradual improvement over time	Often faster but short-lived results
Side Effects	Mild tingling; minimal when used correctly	Potential skin irritation

The bottom line? Hydroquinone is an alternative for short-term use, but Cyspera offers safer long-term care. 

How Does Cyspera Compare to Lasers for Pigmentation Treatment? 

Feature	Cyspera	Lasers
Cost	Moderate and more accessible	High upfront cost
Downtime	None	Temporary redness and swelling
Application	Non-invasive cream	Requires in-clinic procedures

While laser treatments can be effective for specific cases, Cyspera suits those seeking a non-invasive and cost-effective melasma treatment.

Conclusion

Cyspera offers a practical and safe solution for melasma and other skin pigmentation concerns. With its suitability for diverse skin types, compatibility for long-term use and targeted action, it continues to be an option worth exploring for individuals looking to manage pigmentation.

For personalised advice, consult an aesthetic professional who can guide you in determining if Cyspera is the right fit for your skincare needs.